Competitive exclusion of clonal subpopulations in heterogeneous tumours after stromal injury

Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas.

The histolÃ3gica! pleomorphism of human malignant gliomas as well as their variable response to therapy suggests that such tumors are not homogeneous but are composed of a hetero geneous population of cells. To search for heterogeneity in these tumors, we developed a protocol to identify by karyotype, isolate, and clone the subpopulations of the tumor. Freshly resected tumors were mechanically ...

The competitive exclusion principle.

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Gastrointestinal stromal tumours (GIST)

Gastrointestinal Stromal Tumours: An Update

Purpose. To study the evolution of concepts concerning gastrointestinal stromal tumours (GISTs) over 30 years.Discussion. GISTs have been, for more than 30 years, the subject of considerable controversy regarding their line of differentiation as well as the prediction of their behaviour. Furthermore, once they spread within the peritoneal cavity, they are extremely hard to control. The recent f...

Neanderthal Extinction by Competitive Exclusion

BACKGROUND Despite a long history of investigation, considerable debate revolves around whether Neanderthals became extinct because of climate change or competition with anatomically modern humans (AMH). METHODOLOGY/PRINCIPAL FINDINGS We apply a new methodology integrating archaeological and chronological data with high-resolution paleoclimatic simulations to define eco-cultural niches associ...